Select personalised content. Create a personalised content profile. Measure ad performance. Select basic ads. Create a personalised ads profile. Select personalised ads. Apply market research to generate audience insights. Measure content performance. Develop and improve products. List of Partners vendors. Methionine L-methionine is a nutritional supplement as well as an essential amino acid found in food.
There are two types of methionine—L-methionine which is naturally-occurring and D-methionine. Each contains the same chemical make-up, but the molecules are mirror images. A mixture of the two is called DL-methionine. Methionine is a sulfur-containing amino acid that improves the tone and elasticity of the skin, promotes healthy hair and strengthens the nails.
However, methionine is thought to be effective in the treatment of Tylenol acetaminophen poisoning. The sulfur in methionine provides the body with many potential health benefits. Taking an oral by mouth dose of methionine within 10 hours of Tylenol acetaminophen overdose has been used in treating acetaminophen poisoning. However, other treatments are also used and methionine may not be the most effective. Although some of the research is mixed regarding colon cancer and methionine, a meta-analysis reports, "This meta-analysis indicates that dietary methionine intake may be associated with decreased risk of colorectal cancer, especially colon cancer.
More prospective studies with long follow-up time are needed to confirm these findings. Some studies show that a low methionine diet could be beneficial. There are specific types of cancer cells that depend on methionine to grow. Thus, limiting the intake of foods containing methionine is beneficial for those who have some types of cancer, because it results in the death of the cancer cells.
Research on L-methionine and Alzheimer's disease has only been conducted in animal studies. In a mouse model study discovered that a diet enriched with L-methionine resulted in:. Methionine is commonly taken for other disorders, but there is a lack of clinical research study results to back up the safety and efficacy of its use in these conditions:.
Methionine may cause several mild side effects, including nausea and vomiting, drowsiness and irritability. In fact, nausea is reportedly a very common side effect that can occur from taking methionine supplements. A contraindication is a condition or circumstance indicating that a specific technique or drug should not be used.
Methionine is contraindicated for those who have:. Clinical research study results do not point to serious signs of toxicity, except at very high doses of methionine. The adult dosage of methionine for acetaminophen overdose is 2. Select a product that provides potency, safety, and purity. A certified organic product, tested by a third party, such as the U.
This is because unlike medications, supplements are not regulated by any governing agency, like the FDA. In these cases, limiting your dietary intake could be beneficial to help starve cancer cells Since proteins from plants are often lower in methionine than animal proteins, some researchers believe that plant-based diets could be a tool to fight some cancers 15 , Additionally, several studies in animals show that reducing methionine can increase lifespan and improve health 17 , 18 , This longevity may be due to improved stress resistance and metabolism as well as maintaining the ability for cells of the body to reproduce 20 , Some researchers concluded that the low methionine content acts to actually slow the rate of aging in mice In animals, lowering the methionine content of the diet may slow the rate of aging and increase lifespan.
Some studies have shown benefits of lowering methionine in human cells, but research is needed in living humans. While virtually all protein-containing foods have some methionine, the amount varies widely. Eggs, fish and some meats contain high amounts of this amino acid Plant proteins usually have even lower quantities of these amino acids.
Some research has also examined the overall amount of the sulfur-containing amino acids methionine and cysteine in different types of diets The highest content 6. Despite the low intake among vegetarians, other research has shown that they actually have higher blood concentrations of methionine than those who eat meat and fish This finding led the researchers to conclude that dietary content and blood concentrations of methionine are not always directly related.
However, these studies did find that vegans have both low dietary intake and low blood concentrations of methionine 24 , Animal proteins often have greater methionine content than plant proteins. Those following a plant-based diet have a lower dietary intake of sulfur-containing amino acids, although they can have either higher or lower levels of methionine in the blood.
Researchers have set a recommended daily intake of the sulfur-containing amino acids methionine and cysteine , but studies have also examined side effects of higher doses. The daily recommended intake of methionine plus cysteine is 8. However, some researchers have recommended consuming double this amount based on the limitations of the studies used to set the recommended intake The elderly often have low methionine intake, and studies have shown that they may need higher intakes of 2 to 3 grams per day 24 , Despite the fact that certain groups may benefit from increasing their methionine intake, many diets exceed 2 grams per day of methionine plus cysteine.
A variety of diets, including vegan, vegetarian, traditional and high-protein diets are estimated to contain between 2. Perhaps the largest concern associated with high methionine intake is due to one of the molecules this amino acid can produce.
Methionine can be converted into homocysteine, an amino acid associated with several aspects of heart disease 27 , High intakes of methionine may lead to an increase in homocysteine, although some individuals are more susceptible to this process than others Interestingly, research indicates that potential dangers of high methionine intake may be due to homocysteine rather than methionine itself For example, even though they have a lower dietary intake of methionine, vegans and vegetarians may have higher homocysteine than omnivores due to low vitamin B12 intake This type of test has been performed over 6, times, with primarily minor side effects.
These minor side effects include dizziness, sleepiness and changes in blood pressure One major adverse event occurred during one of these tests, which resulted in the death of an individual with high blood pressure but good health otherwise However, it seems likely that an accidental overdose of approximately 70 times the recommended intake caused the complications Overall, it appears that methionine is not particularly toxic in healthy humans, except at extremely high doses that would be virtually impossible to obtain through the diet.
Even though methionine is involved in the production of homocysteine, there is no evidence that intake within a typical range is dangerous for heart health Individuals following many types of diets will often exceed the recommended minimum intake of methionine. Side effects in response to large doses are often minor but could become dangerous at extremely high doses. Methionine is a unique sulfur-containing amino acid that can be used to build proteins and produce many molecules in the body.
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